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Saturday, January 28, 2012

Vaccinations and water safety in Egypt

1. NO vaccinations are required for Egypt. To read what the CDC has to say (they give information on every possible thing that could happen), click here.

2. CDC information on making water "safer" is here. Additionally, one of the participants found these tablets which say they will purify the water and kill microorganisms. Sodium dichloroisocyanurate is the active ingredient. You can also find these at other online stores as well as some brick & mortar establishments. This post is purely for informational purposes and is not an endorsement of this product.

3. Here's another website with information about traveler's diarrhea.

4. Below is information on ways to prevent/treat stomach issues that may arise on the trip.


In regions where invasive pathogens are responsible for a significant proportion of traveler’s diarrhea, quinolones should be used. Azithromycin (Zithromax) is recommended in places where quinoloneresistant Campylobacter is prevalent (e.g., Thailand). Antibiotics used for the treatment of traveler’s diarrhea are listed in below. Trimethoprim-sulfamethoxazole (Bactrim, Septra) and doxycycline are no longer recommended because of the development of widespread resistance.

Antibiotics Used for the Treatment of Traveler’s Diarrhea


Antibiotic
Dosage
Comments
Ciprofloxacin (Cipro)
500 mg twice daily for one to three days
Other quinolones (e.g., ofloxacin [Floxin], norfloxacin [Noroxin], and levofloxacin [Levaquin]) are presumed to be effective as well.
Rifaximin (Xifaxan)
200 mg three times daily for three days
Not effective in persons with dysentery
Azithromycin (Zithromax)
In adults: 500 mg daily for one to three days or 1,000 mg in a single dose In children: 10 mg per kg daily for three days
Antibiotic of choice in children and pregnant women, and for quinolone-resistant Campylobacter


Information from references
     Therapy that involves an antibiotic with loperamide (Imodium) often limits symptoms to one day. Loperamide has antimotility and antisecretory effects and is taken as two 2–mg tablets after the first loose stool, followed by one tablet after each subsequent loose stool (maximum of 8 mg in 24 hours for two days). The use of loperamide in dysentery has been controversial because of concerns about prolonging illness, but it is now considered safe when combined with an antibiotic. A conservative approach would be to use loperamide for dysentery only if combined with an antibiotic and if the traveler has a long trip or will have no toilet access.
     Oral rehydration solutions generally are unnecessary in adults younger than 65 years. However, all travelers with diarrhea should be encouraged to drink plenty of fluids and to replace lost electrolytes using foods such as salt crackers or broth.

Traveler’s Diarrhea in Children and Pregnant Women
     Traveler’s diarrhea is more common in young children than in adults, and they have a higher risk of dehydration and severe illness. Parents should seek immediate medical attention if their child shows signs of moderate to severe dehydration, bloody diarrhea, a temperature higher than 39°C (102°F), or persistent vomiting. Few data exist on the treatment of diarrhea in children. The use of oral rehydration solutions is essential, and parents should include prepackaged packets (to be mixed with safe water) in their travel kits. These packets are available in camping stores in the United States or in pharmacies in other countries.
     Fluoroquinolones are not approved by the U.S. Food and Drug Administration (FDA) for use in children, and rifaximin is approved only for children 12 years and older. Therefore, azithromycin is the drug of choice for most children with traveler’s diarrhea. Another option is nalidixic acid (Neggram) in a dosage of 55 mg per kg per day divided into four doses, not to exceed 1 g in 24 hours. Loperamide is approved for children older than two years, but should not be used in children with dysentery. Bismuth subsalicylate should be avoided for prophylaxis in children because of the possible risk of Reye’s syndrome.
     Pregnant women may be at higher risk of traveler’s diarrhea than nonpregnant women because of lowered gastric acidity and increased gastrointestinal transit time. Quinolones (FDA pregnancy category C) generally are not advised during pregnancy, but azithromycin (FDA pregnancy category B) is safe. Oral rehydration should be emphasized. Although rifaximin is not absorbed, the safety of this medication in pregnant women has not been established. Loperamide (FDA pregnancy category B) may be used, but bismuth subsalicylate (FDA pregnancy category D) should be avoided. Being careful with food and water is particularly important during pregnancy because infections such as listeriosis can cause miscarriage, and hepatitis E can result in maternal mortality.

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